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William G Cance Selected Research

chloropyramine

1/2015Inhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma.
6/2014Design, synthesis, and biological evaluation of novel FAK scaffold inhibitors targeting the FAK-VEGFR3 protein-protein interaction.
8/2009Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo.

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William G Cance Research Topics

Disease

61Neoplasms (Cancer)
01/2021 - 09/2002
17Breast Neoplasms (Breast Cancer)
10/2014 - 09/2002
14Neoplasm Metastasis (Metastasis)
01/2022 - 01/2003
9Carcinogenesis
08/2017 - 11/2004
7Colonic Neoplasms (Colon Cancer)
09/2015 - 08/2003
7Neuroblastoma
01/2015 - 04/2007
5Pancreatic Neoplasms (Pancreatic Cancer)
10/2014 - 06/2008
3Colorectal Neoplasms (Colorectal Cancer)
01/2022 - 01/2003
3Melanoma (Melanoma, Malignant)
01/2014 - 10/2005
3Adenocarcinoma
10/2013 - 09/2004
3Carcinoma (Carcinomatosis)
07/2009 - 09/2004
2Glioblastoma (Glioblastoma Multiforme)
08/2015 - 02/2013
2Primary Hyperparathyroidism
01/2015 - 01/2006
2Neurofibromatosis 1 (Neurofibromatosis Type I)
02/2012 - 11/2009
2Sarcoma (Soft Tissue Sarcoma)
02/2012 - 02/2007
1Neoplasm Micrometastasis
01/2021
1Leukemia
08/2015
1Thyroid Neoplasms (Thyroid Cancer)
09/2014
1Lung Neoplasms (Lung Cancer)
09/2014
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
09/2014
1Brain Neoplasms (Brain Tumor)
02/2013
1Glioma (Gliomas)
02/2013
1Neurofibrosarcoma (MPNST)
02/2012
1Ganglion Cysts (Ganglion)
06/2008

Drug/Important Bio-Agent (IBA)

52Focal Adhesion Protein-Tyrosine KinasesIBA
01/2022 - 01/2003
20Phosphotransferases (Kinase)IBA
12/2016 - 03/2003
18Proteins (Proteins, Gene)FDA Link
08/2017 - 01/2003
16Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
01/2022 - 01/2003
8Vascular Endothelial Growth Factor Receptor-3 (Flt 4)IBA
01/2015 - 02/2006
7Messenger RNA (mRNA)IBA
01/2009 - 01/2003
6Pharmaceutical PreparationsIBA
12/2016 - 03/2008
5Tyrosine (L-Tyrosine)FDA Link
12/2016 - 07/2003
5Biological ProductsIBA
09/2014 - 04/2007
4Small Interfering RNA (siRNA)IBA
03/2014 - 04/2007
4Caspase 3 (Caspase-3)IBA
02/2013 - 08/2003
4Formaldehyde (Formol)FDA Link
06/2008 - 01/2003
4ParaffinIBA
06/2008 - 01/2003
3chloropyramineIBA
01/2015 - 08/2009
3Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
07/2009 - 03/2003
2Adenosine Triphosphate (ATP)IBA
12/2016 - 05/2013
2Monoclonal AntibodiesIBA
10/2014 - 06/2008
2Peptides (Polypeptides)IBA
03/2014 - 02/2006
2decaneIBA
01/2014 - 05/2012
2GemcitabineFDA Link
10/2013 - 08/2009
2Dihydrotachysterol (AT 10)IBA
05/2013 - 03/2008
2Somatomedin Receptors (Somatomedin Receptor)IBA
09/2012 - 02/2012
2Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
05/2012 - 06/2008
2Neurofibromin 1 (Neurofibromin)IBA
02/2012 - 11/2009
2Indicators and Reagents (Reagents)IBA
03/2010 - 04/2007
2Insulin (Novolin)FDA Link
02/2010 - 10/2009
2Doxorubicin (Adriamycin)FDA LinkGeneric
08/2009 - 07/2004
21,2,4,5-benzenetetraamineIBA
08/2009 - 12/2008
2src-Family KinasesIBA
03/2008 - 03/2004
2TAE226IBA
03/2008 - 03/2008
2Fluorouracil (Carac)FDA LinkGeneric
10/2005 - 07/2004
2Protein Kinases (Protein Kinase)IBA
07/2003 - 03/2003
1Biomarkers (Surrogate Marker)IBA
01/2022
1Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
01/2021
1Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
01/2021
1tyrosine receptor (receptor, tyrosine)IBA
12/2016
1valspodar (PSC 833)IBA
09/2015
1goralatideIBA
08/2015
1defactinibIBA
09/2014
1Drug CombinationsIBA
09/2014
1Sorafenib (BAY 43-9006)FDA Link
09/2014
1pazopanibFDA Link
09/2014
1cabozantinibIBA
09/2014
1Sunitinib (Sutent)FDA Link
09/2014
1nutlin 1IBA
01/2014
1Cytostatic AgentsIBA
10/2013
1Mitoxantrone (Novantrone)FDA LinkGeneric
05/2013
1HymecromoneIBA
05/2013
1Hyaluronic Acid (Hyaluronan)IBA
05/2013
1Proto-Oncogene Proteins c-mdm2IBA
05/2013
1Temozolomide (Temodar)FDA LinkGeneric
02/2013
1Insulin-Like Growth Factor I (IGF-1)IBA
09/2012
1Therapeutic UsesIBA
09/2012
14- (methylthio)- 7- (5- O- phosphonoribofuranosyl)- 7H- pyrrolo(2,3- d)pyrimidineIBA
09/2012
1BromidesIBA
05/2012
1Insulin ReceptorIBA
02/2012
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
02/2012
1AG 1879IBA
03/2010
1Epoetin Alfa (Epogen)FDA Link
12/2009
1N 30IBA
10/2009
1Drinking WaterIBA
08/2009
1Tetracycline (Achromycin)FDA LinkGeneric
08/2009
1Doxycycline (Periostat)FDA LinkGeneric
08/2009
1Cyclin DIBA
08/2009
1Hormones (Hormone)IBA
07/2009
1LigandsIBA
07/2009

Therapy/Procedure

24Therapeutics
01/2021 - 09/2002
8Drug Therapy (Chemotherapy)
01/2015 - 10/2005
4Neoadjuvant Therapy
02/2007 - 09/2002
3Radiotherapy
09/2012 - 09/2004
2Parathyroidectomy
01/2015 - 01/2006
1Continuity of Patient Care
01/2021
1Aftercare (After-Treatment)
10/2013
1Oral Administration
02/2013
1Intraperitoneal Injections
09/2012
1Blood Transfusion (Blood Transfusions)
12/2009